177Lu Dotatate, also known as Lutathera, is a radiopharmaceutical therapy that has been approved by the FDA for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adults.
Some key points about Lutathera's FDA-approved indications:
- Lutathera is indicated for the treatment of somatostatin receptor-positive GEP-NETs, including foregut, midgut, and hindgut neuroendocrine tumors
- It is approved for unresectable or metastatic GEP-NETs
- The approval is for adult patients
- Patients should have positive somatostatin receptor imaging prior to treatment
In the pivotal trial that led to its approval (NETTER-1),
Lutathera demonstrated:
- Significantly improved progression-free survival compared to high-dose octreotide LAR
- Acceptable safety profile with mostly reversible hematologic toxicity
The specific indications statement in Lutathera's FDA-approved labeling is:
"LUTATHERA is indicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adults."
Some additional context around Lutathera and neuroendocrine tumors:
- GEP-NETs are rare tumors arising from neuroendocrine cells in the digestive system
- Over 25% of GEP-NETs overexpress somatostatin receptors which Lutathera targets
- Approximately 10,000 people per year in the US are candidates for peptide receptor radionuclide therapy
- Lutathera binds to somatostatin receptors and delivers targeted radiation directly to tumors
If you have been diagnosed with
inoperable, metastasized GEP-NETs and are looking for advanced treatment options,
speak to your oncologist about whether 177Lu Dotatate/Lutathera PRRT is right for you.
Here at
Revive Hormone Clinic, we understand coping with a rare cancer diagnosis like NETs can be frightening and emotionally taxing. Our caring doctors are here to provide
integrative, personalized support throughout your treatment, including:
- Nutritional counseling
- Emotional wellness services
- Naturopathic medicine
- Support groups
We will help empower each NETs patient to not just survive, but thrive in the midst of this challenging diagnosis.
Schedule a consultation at our hormone clinic today.
